Optimizing the Sensitivity of Patch Testing – Where We Are and Where We Want To Be

Patch testing has proven to be a valuable tool for deciphering the culprit agent for cutaneous drug reactions such as morbilliform drug eruption, drug reaction with eosinophilia and systemic symptoms and acute generalized exanthematous pustulosis.  Although a safe procedure concentrations of patch test reagents have not been validated for all drugs and the sensitivity of the patch testing procedure is very much dependent on the clinical phenotype as well as the drug.  The modifiers that drive differing sensitivities across drugs and phenotypes are not currently known although it is postulated that this relates to the role of specific drugs and reactive metabolites and their disposition in the skin that may relate to their chemical properties as well as antigen driven resident T cells in the skin.  Historically dating back to the first use of patch testing for diagnosis of contact dermatitis procedures were explored to increase exposure of the skin to the suspected culprit product.    This webinar will explore the art and science of drug patch testing and open out discussion about mechanisms to further increase the sensitivity of patch testing and utilize it as a tool to understand the mechanisms of cutaneous drug reactions.

 

 

This webinar series will be delivered by key opinion leaders in the area of delayed drug hypersensitivity syndromes, such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS and TEN), acute generalized exanthematous pustulosis (AGEP), and morbilliform drug eruption (MDE), amongst others.  The format will be webinars with one to four speakers and moderators per session who will deliver a topic to advance knowledge in the area (as per the topics listed and objectives below) and generate an active discussion afterwards. This discussion will identify further unmet needs and opportunities to be pursued by a specific subset of the working group in between webinars.  

Each session would be 1 hour followed by 30 minutes of discussion.

 

Target Audience

  • Allergist/Immunologists
  • Primary Care Providers
  • Fellows-in-Training
  • Nurses and Nurse Practitioners
  • Physician Assistants and Other Allied Health Professionals 

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Describe the background in clinical utility of drug patch testing as a tool to define the culprit drug associated with a cutaneous drug eruption as well as cross-reactivity patterns
  • Identify the specific drugs and clinical phenotypes where patch testing may have the highest utility as a diagnostic tool
  • Explain the current limitations of patch testing
  • Discuss opportunities to increase the sensitivity of patch testing in clinical practice
Summary
Available credit: 
  • 1.50 Attendance
    Attendance credit.
  • 1.50 CME
    CME credit.
Course opens: 
10/21/2022
Course expires: 
06/30/2023
Member cost:
$0.00
Cost:
$0.00
Rating: 
0

Planning Committee

Elizabeth J. Phillips, MD FAAAAI FIDSA
Vanderbilt University
Relevant Relationships: None

 

Faculty

Jonathan G. Peter, MD PhD
University of Cape Town/Western Cape Provincial Health
Relevant Relationships: None

Rannakoe Lehloenya, MBChB
University of Cape Town
Relevant Relationships: None

 

Content Reviewer

Brian Schroer, MD
Cleveland Clinic Foundation, Cleveland, OH
Relevant relationships: Sanofi, ReadySetFood: asthma & food allergy
 

The information disclosed by the presenters and planning committee members was reviewed in accordance with the AAAAI Disclosure Policy. All potential conflicts of interest were mitigated by the planners, faculty, and reviewers prior to their participation in the development of this activity.

AAAAI Disclosure Policy

Pursuant to the Code of Ethics for the American Academy of Allergy, Asthma & Immunology (AAAAI) and the Standards for Commercial Support of Continuing Medical Education of the Accreditation Council for Continuing Medical Education, the AAAAI requires disclosure of certain information from faculty members of educational activities designated for CME credit by the AAAAI. Prior to the activity, authors and reviewers are required to disclose all relationships that meet the following parameters:

  • Employment: Name of employer and job title.
  • Financial interests: All organizations, other than the employer, from which the faculty member or a member of his/her immediate family or household receives annual remuneration in any amount (including grants, honoraria and consulting fees).
  • Research interests: All organizations which support research projects for which the faculty member or member of his/her immediate family or household serves as an investigator.
  • Legal Consultation Services/Expert Witness Testimony: All topics on which the faculty member provided legal consultation and/or expert witness testimony during the previous calendar year.
  • Organizational interests: All organizations, other than the AAAAI, for which the faculty member holds volunteer positions.
  • Gifts: All organizations from which the faculty member or a member of his/her immediate family or household have received a gift of any amount in the last year.
  • Other interests: All interests of the faculty member or a member of his/her immediate family or household that would be judged by a majority of his/her peers to be more than casual and/or likely to impact his/her ability to exercise independent judgment. This includes any financial interest in or relationship with any manufacturer of a commercial product, and any financial interest or relationship with any organization that provides commercial support to AAAAI-sponsored educational activities.
Accreditation Statement

The American Academy of Allergy, Asthma and Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation Statement

The American Academy of Allergy, Asthma & Immunology designates this Other (live webinar & recorded videos) activity for a maximum of 1.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Credit Claiming Period

Credit claiming for this activity will expire at 11:59 pm on June 30, 2023. Requests to claim credit on or after July 1, 2023 will be subject to an administrative fee.

Questions

Registration and credit claiming questions should be directed to cme@aaaai.org.

Available Credit

  • 1.50 Attendance
    Attendance credit.
  • 1.50 CME
    CME credit.

Price

Member cost:
$0.00
Cost:
$0.00
Please login or register to take this course.

By registering for this educational activity you are confirming that you have read the Privacy and Data Protection Notice and agree to the terms as outlined below:

Privacy and Data Protection Notice

The American Academy of Allergy, Asthma & Immunology (AAAAI) takes your privacy seriously. AAAAI will only use your personal information to administer your registration, attendance, and credit claiming/attendance record for this activity, to provide services that you have requested from AAAAI and otherwise as you may expressly consent. A complete copy of AAAAI’s Legal and Privacy Notices, the terms of which are incorporated herein, can be found here.

By providing consent, you are allowing AAAAI to process your personal data. AAAAI will collect and store information you provide in the Registration/Housing Forms for the purposes of enabling us to register your attendance at the activity; to assist with administrative, planning and marketing purposes; and to allow the compilation and analysis of statistics relevant to AAAAI.

The information you provide in the Registration/Housing Forms, and information provided at any other time during this activity, including without limitation any feedback obtained during the activity, will be used by AAAAI to offer, provide and continue to improve its educational activities and other services. The AAAAI will also use your email address to communicate important information regarding this activity and for marketing purposes for future activities. AAAAI will not otherwise, without your consent, use or disclose your personal information for any purpose unless it would reasonably be expected that such a purpose is related to the offer, provision and improvement of the activity or where such purpose is permitted or required by law.

For courses/events with industry support and/or exhibitors, The AAAAI may disclose some information that is collected in the Registration Form such as your name, credentials, title/position, organization, and mailing address to exhibitors and industry supporters for marketing purposes such as to receive mailed literature. In addition to, but separate from, your consent regarding being contacted by exhibitors and industry supporters with mailed literature, when you visit sponsored areas within the virtual platform for an online event (such as, but not limited to, an exhibitor’s virtual exhibit booth), that organization will receive your personal contact information (name, credentials, title/position, organization, mailing address, phone number, email address and NPI number, if applicable). If you do not want to share your personal contact information with any/all of those organizations, please do not visit those areas within our virtual platform. By accessing any/all of those areas in our virtual platform, you are consenting to share your personal contact information with all organizations whose sponsored areas you visit in our virtual platform. If you attend this activity in person, and provide your contact information to an exhibitor or industry supporter (including allowing them to scan your name badge), you are consenting to share your personal contact information with that organization. You have the right to decline an exhibitor and/or industry supporter’s request for your personal contact information. AAAAI does not control the use or distribution of personal contact information transferred when you visit a sponsored area in the virtual platform or, if in person, when you share your personal contact information, and as such, AAAAI shall not be held responsible for any misuse of your personal data obtained by exhibitors or industry supporters in this manner. You have the right to ask the exhibitor or industry supporter questions about how they will use your personal data, how long it will be retained and if they will share information with third parties.

After you have submitted your personal contact information in the registration form, you may change your preferences for receiving emails by following the instructions below:
·    To change your preferences for receiving emails from AAAAI regarding future annual meetings and/or other in-person and online education programs, please visit http://aaaai.execinc.com/edibo/Profile
·    For events where industry support or exhibitions are involved please email cme@aaaai.org to change your consent to be contacted by the industry supporters and exhibitors of that activity.

NOTE: AAAAI may be photographing this activity. These photographs, along with your name, may be used in AAAAI publications or on the AAAAI website. If you do not want your photo used, please inform the staff photographer at the time the photograph is taken. AAAAI may also be audio recording education sessions during this activity. If you verbally submit any questions for Question & Answer sessions (Q&A), you are agreeing to be recorded and to have that recording available in enduring materials. If you prefer not to be audio recorded, please submit any questions you have in writing.

I understand that it is my right to withhold consent to the above Privacy and Data Protection Notice, or to withdraw my previous consent at any time. I further understand that without my consent, it is not possible to process my registration/housing request for this activity. Please contact the AAAAI Education Team at (414) 272-6071 if you have any further questions about how this will affect your registration/housing request for this activity.

Required Hardware/software

One of the two latest versions of Google Chrome, Microsoft Edge, Mozilla Firefox, or Safari.

Internet Explorer is no longer supported.