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Signs and Symptoms of PIDD

In a 2021 survey of 300 PIDD patients, 41% of the adults reported that it took over 21 years beyond the onset of their first symptom to receive a final PIDD diagnosis, 59% reported that their PIDD was initially diagnosed as a different disorder, and many felt their symptoms were dismissed by healthcare providers. These findings indicate the importance of shortening time to diagnosis.  

This module reviews signs and symptoms of PIDD and highlights the most important questions to ask patients to understand their full range of symptoms. Importantly, it covers commonly-missed symptoms and outlines treatment options for PIDDs. Finally, it shares suggestions for providing whole-patient care and testimonials from PIDD patients who share portions of their health journey and recommendations for HCPs working with PIDD patients. 

Providing Enhanced Medical Support for Patients with Primary Immunodeficiency Disorders (PIDD) is funded through an educational grant from Pfizer. 

Target Audience

  • Allergist/Immunologists
  • Primary Care Providers
  • Fellows-in-Training
  • Nurses and Nurse Practitioners
  • Physician Assistants and Other Allied Health Professionals 

Learning Objectives

Upon completion of this activity, participants should be able to:

  1. Identify signs and symptoms of PIDD, including those that are commonly-missed
  2. Choose communication strategies that facilitate patient disclosure of symptoms
  3. Recognize the needs of patients with primary immunodeficiencies and identify strategies to optimize their care
  4. Be familiar with existing patient resources that will help patients engage in their diagnosis and care
Available credit: 
  • 0.50 Attendance
    Attendance credit.
  • 0.50 CME
    CME credit.
Course opens: 
Course expires: 
Accreditation Statement

The American Academy of Allergy, Asthma and Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation Statement

The American Academy of Allergy, Asthma & Immunology designates this activity for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CE Designation Statement

The American Academy of Allergy, Asthma, & Immunology (AAAAI) is a Provider, approved by the California Board of Registered Nursing, Provider #10704, for up to 0.50 Contact Hours.

Credit Claiming Period

Credit claiming for the online courses associated with this activity will expire at 11:59 pm on August 31, 2023. Requests to claim credit on or after September 1, 2023 will be denied.

Medium and Method of Physician Participation

Follow these steps to complete the activity:

  1. Register for the activity.
  2. Review the information in the Faculty and Accreditation tabs.
  3. Click Begin (from the Overview, Register, or Begin tabs).
  4. Complete the instruction and the assessment. You must achieve a score of 70% or higher to claim credit.
  5. Complete the evaluation.
  6. Claim your credit.
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Available Credit

  • 0.50 Attendance
    Attendance credit.
  • 0.50 CME
    CME credit.


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