Plenary 3101: More Than a Barrier: The Roles of Airway Epithelium in Healthy and Allergic Metabolic and Immune Responses
This session will outline the roles of novel airway epithelial cell subsets, including chemosensory tuft cells, ion-transporting ionocytes and pulmonary neuroendocrine cells in asthma and other respiratory diseases. The presenters will describe how these subsets sense environmental cues, including allergens, microbial metabolites, ions and neurotransmitters, and how they process this information to regulate ionic balance, mucosal leukocytes and type-2 immune responses in health, inflammatory and allergic airway disease.
|AAAAI Foundation and Michael M. Frank, MD FAAAAI Lectureship||Nora Barrett, MD||A Single-Cell Expression Atlas of Epithelial Cells to Explain Mechanisms of an Airway Disease|
|AAAAI Foundation and Donald Y. M. Leung, MD PhD FAAAAI-JACI Lecture: Investing Together in Our Future||Xin Sun, PhD||Pulmonary Neuroendocrine Cells: Translating Neuronal and Environmental Cues into Immune Responses in Asthma and Other Lung Diseases|
|AAAAI Foundation and Richard F. Lockey, MD MS FAAAAI & University of South Florida Lectureship||Noam Cohen, MD PhD||Epithelial Taste-Chemosensory Cells in Regulation of Allergic Inflammation|
- A/I physicians
- A/I fellows-in-training
- A/I nurses, nurse practitioners and physician assistants
Upon completion of this activity, participants should be able to:
- Describe new epithelial subsets and characterize their molecular programs
- Describe novel functions of epithelial cell subsets in recognition of environmental signals and activation of mucosal immune cells
- Define roles of new epithelial subsets in asthma and other respiratory diseases
Nora Barrett, MD FAAAAI
Harvard University, Boston, MA
Relevant relationships: None
Noam A. Cohen, MD PhD
University of Pennsylvania, Philadelphia, PA
Relevant relationships: GeneOne Life Sciences (royalty), Sanofi/Regeneron (advisory board)
Xin Sun, PhD
University of California, San Diego, CA
Relevant relationships: None
Bruce Lanser, MD FAAAAI
National Jewish Health, Denver, CO
Relevant relationships: Aimmune: peanut oral immunotherapy
Brian Schroer, MD
Cleveland Clinic Foundation, Cleveland, OH
Relevant relationships: None
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The American Academy of Allergy, Asthma & Immunology designates this live activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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Credit Claiming Period
Credit claiming for this activity will expire at 11:59 pm on April 30, 2022. Requests to claim credit on or after May 1, 2022 will be denied.
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- 1.25 AttendanceAttendance credit.
- 1.25 CECE credit.
- 1.25 CMECME credit.