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Plenary 3101: More Than a Barrier: The Roles of Airway Epithelium in Healthy and Allergic Metabolic and Immune Responses
This session will outline the roles of novel airway epithelial cell subsets, including chemosensory tuft cells, ion-transporting ionocytes and pulmonary neuroendocrine cells in asthma and other respiratory diseases. The presenters will describe how these subsets sense environmental cues, including allergens, microbial metabolites, ions and neurotransmitters, and how they process this information to regulate ionic balance, mucosal leukocytes and type-2 immune responses in health, inflammatory and allergic airway disease.
| Lectureship | Speaker | Title |
|---|---|---|
| AAAAI Foundation and Michael M. Frank, MD FAAAAI Lectureship | Nora Barrett, MD | A Single-Cell Expression Atlas of Epithelial Cells to Explain Mechanisms of an Airway Disease |
| AAAAI Foundation and Donald Y. M. Leung, MD PhD FAAAAI-JACI Lecture: Investing Together in Our Future | Xin Sun, PhD | Pulmonary Neuroendocrine Cells: Translating Neuronal and Environmental Cues into Immune Responses in Asthma and Other Lung Diseases |
| AAAAI Foundation and Richard F. Lockey, MD MS FAAAAI & University of South Florida Lectureship | Noam Cohen, MD PhD | Epithelial Taste-Chemosensory Cells in Regulation of Allergic Inflammation |
Target Audience
- A/I physicians
- A/I fellows-in-training
- A/I nurses, nurse practitioners and physician assistants
Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe new epithelial subsets and characterize their molecular programs
- Describe novel functions of epithelial cell subsets in recognition of environmental signals and activation of mucosal immune cells
- Define roles of new epithelial subsets in asthma and other respiratory diseases
Faculty
Nora Barrett, MD FAAAAI
Harvard University, Boston, MA
Relevant relationships: None
Noam A. Cohen, MD PhD
University of Pennsylvania, Philadelphia, PA
Relevant relationships: GeneOne Life Sciences (royalty), Sanofi/Regeneron (advisory board)
Xin Sun, PhD
University of California, San Diego, CA
Relevant relationships: None
Reviewers
Bruce Lanser, MD FAAAAI
National Jewish Health, Denver, CO
Relevant relationships: Aimmune: peanut oral immunotherapy
Brian Schroer, MD
Cleveland Clinic Foundation, Cleveland, OH
Relevant relationships: None
AAAAI Disclosure Policy
Pursuant to the Code of Ethics for the American Academy of Allergy, Asthma & Immunology (AAAAI) and the Standards for Commercial Support of Continuing Medical Education of the Accreditation Council for Continuing Medical Education, the AAAAI requires disclosure of certain information from faculty members of educational activities designated for CME credit by the AAAAI. Prior to the activity, authors and reviewers are required to disclose all relationships that meet the following parameters:
- Employment. Name of employer and job title.
- Financial interests. All organizations, other than the employer, from which the faculty member or a member of his/her immediate family or household receives annual remuneration in any amount (including grants, honoraria and consulting fees).
- Research interests. All organizations which support research projects for which the faculty member or member of his/her immediate family or household serves as an investigator.
- Legal Consultation Services/Expert Witness Testimony: All topics on which the faculty member provided legal consultation and/or expert witness testimony during the previous calendar year.
- Organizational interests: All organizations, other than the AAAAI, for which the faculty member holds volunteer positions.
- Gifts. All organizations from which the faculty member or a member of his/her immediate family or household have received a gift of any amount in the last year.
- Other interests. All interests of the faculty member or a member of his/her immediate family or household that would be judged by a majority of his/her peers to be more than casual and/or likely to impact his/her ability to exercise independent judgment. This includes any financial interest in or relationship with any manufacturer of a commercial product, and any financial interest or relationship with any organization that provides commercial support to AAAAI-sponsored educational activities.
The information disclosed by the speakers and planning committee was reviewed in accordance with the AAAAI Disclosure Policy. All potential conflicts of interest were resolved by the planners, faculty, and reviewers prior to their participation in the development of this activity.
Accreditation Statement
The American Academy of Allergy, Asthma and Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Designation Statement
The American Academy of Allergy, Asthma & Immunology designates this live activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
CE Designation Statement
The American Academy of Allergy, Asthma, & Immunology (AAAAI) is a Provider, approved by the California Board of Registered Nursing, Provider #10704, for up to 1.25 Contact Hours.
Credit Claiming Period
Credit claiming for this activity will expire at 11:59 pm on April 30, 2022. Requests to claim credit on or after May 1, 2022 will be denied.
AAAAI Privacy Policy
To verify your participation in educational activities, you may be asked to provide your name, contact information, and/or other descriptors. The AAAAI will not release this information to outside entities. It may be used internally to inform you of other AAAAI educational activities. If you wish to have your information excluded from this process, please contact us at cme@aaaai.org.
Questions
Activity-related questions should be directed to cme@aaaai.org.
Available Credit
- 1.25 AttendanceAttendance credit.
- 1.25 CECE credit.
- 1.25 CMECME credit.