Penicillin Allergy Center - image of medication bottle and pills with wording Penicillin Allergy Center

What's New in Penicillin Allergy



Updates in Adult
Penicillin Allergy 

Updates in Pediatric
Penicillin Allergy 

A photo of Dr. Allison Ramsey with a play button to watch her discuss Risk Stratification 

A photo of Dr. Allison Norton with a play button to watch her discuss Penicillin Challenges in Children

Worth a Read (or Listen)

AAAAI Podcast Episode: Penicillin Allergy: Often Suspected, Rarely Confirmed
Drug allergy expert David A. Khan, MD, FAAAAI, discusses how our understanding and evaluation of penicillin allergy has rapidly evolved in recent years.

AAAAI Drug Allergy: An Updated Practice Parameter (2010)
The latest evidence-based recommendations on diagnosing and treating penicillin and other drug allergies.

Penicillin Allergy Testing Is Cost-Saving: An Economic Evaluation Study
Sousa-Pinto B, Blumenthal KG, Macy E, et al. Clinical Infectious Diseases. March 15, 2021

Penicillin Allergy Assessment in Pregnancy: Safety and Impact on Antibiotic Use
Wolfson AR, Mancini CM, Banerji A, et al. JACI: In Practice. March 2021

Direct Challenges to Penicillin-Based Antibiotics in the Inpatient Setting
Ramsey A, Mustafa SS, Holly AM, Staicu ML. JACI: In Practice. July-August 2020

Development and Validation of a Penicillin Allergy Clinical Decision Rule
Trubiano JA, Vogrin S, Chua KYL, et al. JAMA Internal Medicine. May 1, 2020

A Streamlined Approach to Optimize Perioperative Antibiotic Prophylaxis in the Setting of Penicillin Allergy Labels
Kuruvilla M, Sexton M, Wiley Z, et al. JACI: In Practice. April 2020

Electronic Consultations in Allergy/Immunology
Phadke NA, Wolfson AR, Mancini C, et al. JACI: In Practice. November-December 2019

Comparing Direct Challenge to Penicillin Skin Testing for the Outpatient Evaluation of Penicillin Allergy: A Randomized Controlled Trial 
Mustafa SS, Conn K, Ramsey A. JACI: In Practice. September-October 2019

Antibiotic Allergy
Blumenthal K, Peter J, Trubiano J, Phillips E. Lancet. January 12, 2019

Controversies in Drug Allergy: Drug Allergy Pathways
Chiriac AM, Banerji A, Gruchalla RS, et al. JACI: In Practice. January 2019

Evaluation and Management of Penicillin Allergy: A Review
Shenoy ES, Macy E, Rowe T, Blumenthal KG. JAMA. January 15, 2019

Addressing Inpatient Beta-Lactam Allergies: A Multihospital Implementation
Blumenthal KG, Shenoy ES, Wolfson AR, et al. JACI: In Practice. 2017

A Proactive Approach to Penicillin Allergy Testing in Hospitalized Patients
Chen JR, Tarver SA, Alvarez KS, et al. JACI: In Practice. 2017

Assessing the Diagnostic Properties of Graded Oral Provocation Challenge for the Diagnosis of Immediate and Nonimmediate Reactions to Amoxicillin in Children
Mill C, Primeau MN, Medoff E, et al. JAMA Pediatrics. 2016

Don’t Overuse Antibiotics in Patients with a History of Penicillin Allergy, without an Appropriate Evaluation. Choosing Wisely, An Initiative of the ABIM Foundation. 2014.

Health Care Use and Serious Infection Prevalence Associated with Penicillin “Allergy” in Hospitalized Patients. A Cohort Study.
Macy, E & Contreras, R. JACI. 2013.

Evaluation and Diagnosis of Penicillin Allergy for Healthcare Professionals (CDC)

PDF icon AAAAI-Compiled Penicillin Allergy References May 2021.pdf
This bibliography includes the latest evidence on the mechanisms, diagnosis, and treatment of penicillin allergy.

Ready-to-Use Materials

Ready to Print or Post

Brochure: Penicillin Allergy: What Do You Need to Know?

Infographic: Are You Allergic to Penicillin? 

 Infographic about penicillin allergy​​​​​​​

Coming Soon! Poster 11"x14"​​​​​​​

Links to Share

Drug Allergy Symptoms, Diagnosis, and Treatment

Video: What is a drug allergy? 

Penicillin Allergy - What Do You Need to Know?

Penicillin Allergy FAQ

Advocate With Us

AAAAI Position Statement
Penicillin Allergy Testing Should Be Performed Routinely in Patients with Self-Reported Penicillin Allergy

File Letter to the Editor Template
The Adverse Reactions to Drugs, Biologics & Latex has provided this template Letter to the Editor for you to use in your community. Use this as a starting point and add information pertinent to your local community, and send it to newspapers and also community email news outlets.

Before emailing your local online media outlets, download resources from the AAAAI Penicillin Allergy Center to your practice’s website. Provide a link to your practice website when you email your Letter to the Editor. 

Email us links or pictures of your letter to editor in your local paper at

Penicillin Allergy Testing Campaigns

AAAAI Advocacy