Penicillin Allergy Center - image of medication bottle and pills with wording Penicillin Allergy Center

What's New in Penicillin Allergy



Updates in Adult
Penicillin Allergy 

Updates in Pediatric
Penicillin Allergy 

A photo of Dr. Allison Ramsey with a play button to watch her discuss Risk Stratification 

A photo of Dr. Allison Norton with a play button to watch her discuss Penicillin Challenges in Children

Worth a Read (or Listen)

AAAAI Podcast Episode 56: Penicillin Allergy: Often Suspected, Rarely Confirmed
Drug allergy expert David A. Khan, MD, FAAAAI, discusses how our understanding and evaluation of penicillin allergy has rapidly evolved in recent years.

Episode 5: Penicillin Allergy Through Oral Challenges
Elina Jerschow, MD, FAAAAI, joins the podcast to discuss her latest research study, which demonstrated that 97% of patients with a history of reported mild reactions to penicillin could safely receive penicillin again.

Episode 4: Penicillin Allergies: Over-diagnosed and Under-addressed
Listen to expert Kimberly G. Blumenthal, MD, MSc, FAAAAI, discuss the complicated reasons why penicillin allergies are over-reported and the many ways in which this can be addressed.

AAAAI Drug Allergy: An Updated Practice Parameter (2010)
The latest evidence-based recommendations on diagnosing and treating penicillin and other drug allergies.

Core IM Podcast Episode: 5 Pearls on Penicillin Allergy
Dr. Ann Marie Kumfer, Dr. Kim Blumenthal, Dr. Neda Frayha, Dr. Shreya P. Trivedi and Dr. Dan Taupin. June 2, 2021

Penicillin Allergy Testing Is Cost-Saving: An Economic Evaluation Study
Sousa-Pinto B, Blumenthal KG, Macy E, et al. Clinical Infectious Diseases. March 15, 2021

Penicillin Allergy Assessment in Pregnancy: Safety and Impact on Antibiotic Use
Wolfson AR, Mancini CM, Banerji A, et al. JACI: In Practice. March 2021

Direct Challenges to Penicillin-Based Antibiotics in the Inpatient Setting
Ramsey A, Mustafa SS, Holly AM, Staicu ML. JACI: In Practice. July-August 2020

Development and Validation of a Penicillin Allergy Clinical Decision Rule
Trubiano JA, Vogrin S, Chua KYL, et al. JAMA Internal Medicine. May 1, 2020

A Streamlined Approach to Optimize Perioperative Antibiotic Prophylaxis in the Setting of Penicillin Allergy Labels
Kuruvilla M, Sexton M, Wiley Z, et al. JACI: In Practice. April 2020

Electronic Consultations in Allergy/Immunology
Phadke NA, Wolfson AR, Mancini C, et al. JACI: In Practice. November-December 2019

Comparing Direct Challenge to Penicillin Skin Testing for the Outpatient Evaluation of Penicillin Allergy: A Randomized Controlled Trial 
Mustafa SS, Conn K, Ramsey A. JACI: In Practice. September-October 2019

Penicillin Allergy Evaluation: A Prospective, Multicenter, Open-Label Evaluation of a Comprehensive Penicillin Skin Test Kit 
Solensky R, Jacobs J, Lester M, et al. JACI: In Practice. July-August 2019

Evaluation and Management of Penicillin Allergy: A Review
Shenoy ES, Macy E, Rowe T, Blumenthal KG. JAMA. January 15, 2019

Antibiotic Allergy
Blumenthal K, Peter J, Trubiano J, Phillips E. Lancet. January 12, 2019

Controversies in Drug Allergy: Drug Allergy Pathways
Chiriac AM, Banerji A, Gruchalla RS, et al. JACI: In Practice. January 1, 2019

Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy: Population Based Matched Cohort Study
Blumenthal KG, Lu N, Zhang Y, Li Y, Walensky RP, Choi HK. BMJ. June 2018

The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk 
Blumenthal KG, Ryan EE, Li Y, et al. Clinical Infectious Diseases. February 2018

Addressing Inpatient Beta-Lactam Allergies: A Multihospital Implementation
Blumenthal KG, Shenoy ES, Wolfson AR, et al. JACI: In Practice. 2017

A Proactive Approach to Penicillin Allergy Testing in Hospitalized Patients
Chen JR, Tarver SA, Alvarez KS, et al. JACI: In Practice. 2017

Assessing the Diagnostic Properties of Graded Oral Provocation Challenge for the Diagnosis of Immediate and Nonimmediate Reactions to Amoxicillin in Children
Mill C, Primeau MN, Medoff E, et al. JAMA Pediatrics. 2016

Don’t Overuse Antibiotics in Patients with a History of Penicillin Allergy, without an Appropriate Evaluation. Choosing Wisely, An Initiative of the ABIM Foundation. 2014.

Health Care Use and Serious Infection Prevalence Associated with Penicillin “Allergy” in Hospitalized Patients. A Cohort Study.
Macy, E & Contreras, R. JACI. 2013.

Evaluation and Diagnosis of Penicillin Allergy for Healthcare Professionals (CDC)

PDF icon AAAAI-Compiled Penicillin Allergy References May 2021.pdf
This bibliography includes the latest evidence on the mechanisms, diagnosis, and treatment of penicillin allergy.

Ready-to-Use Materials

Ready to Print or Post

Brochure: Penicillin Allergy: What Do You Need to Know?

PosterAre You Really Allergic to Penicillin?

Infographic: Are You Allergic to Penicillin? 

 Are You Allergic to Penicillin? Infographic

Join us in promoting National Penicillin Allergy Day (September 28) by posting the social media graphics we've created.

Penicillin Allergy Day: Twitter | Facebook/Instagram

Identify Penicillin AllergyTwitter | Facebook/Instagram

Patient Experience: Twitter | Facebook/Instagram

Adverse Events Related to Penicillin Allergy Labeling: Twitter | Facebook/Instagram

Worsening Antimicrobial ResistanceTwitter | Facebook/Instagram

Costs Associated with Penicillin Allergy: Twitter | Facebook/Instagram

Medical CostsTwitter | Facebook/Instagram

Links to Share

Healio: Q&A: National Penicillin Allergy Day Spotlights Need to Re-evaluate Patients

Drug Allergy Symptoms, Diagnosis, and Treatment

Video: What is a drug allergy? 

Penicillin Allergy - What Do You Need to Know?

Penicillin Allergy FAQ

Practice Resources

Advocate With Us

AAAAI Position Statement
Penicillin Allergy Testing Should Be Performed Routinely in Patients with Self-Reported Penicillin Allergy

Penicillin Allergy Testing Campaigns
September 28 is National Penicillin Allergy Day. The AAAAI has sent this letter to 667 offices on Capitol Hill to share information about how penicillin allergy testing can improve patient outcomes, reduce healthcare spending, and help fight antimicrobial resistance. You can also view the video from the our message to Congress here.

File Letter to the Editor Template
The Adverse Reactions to Drugs, Biologics & Latex has provided this template Letter to the Editor for you to use in your community. Use this as a starting point and add information pertinent to your local community, and send it to newspapers and also community email news outlets.

Before emailing your local online media outlets, download resources from the AAAAI Penicillin Allergy Center to your practice’s website. Provide a link to your practice website when you email your Letter to the Editor. 

Email us links or pictures of your letter to editor in your local paper at

AAAAI Advocacy