This session will provide a major update regarding our understanding of T-Cell biology, with a translational focus on T-Cell engineering and the use of these clinical tools in personalized medicine. Topics will include the biology of T-Cells with a focus on the 'translatable' aspects of working with T-Cells in personalized medicine, harnessing targeted T-Cell killing of lymphoma using CAR-T-Cells and the state-of-the-art for viral-specific T-Cells and their use in specific populations including transplant and immunodeficiency patients.

LEARNING OBJECTIVES:
Upon completion of this activity, participants should be able to:

• Discuss the T-Cell features amenable to engineering/personalized medicine
• Discuss the latest advances in CAR-T-Cells used in the treatment of lymphoma
• Discuss viral specific T-Cells and their use in specific populations

Moderator Introduction
Elena  E. Perez, MD PhD FAAAAI
Allergy Associates of Palm Beaches

Chimeric Antigen Receptors: T-Cells Used in the Treatment of Lymphoma
Marco Ruella, MD
University of Pennsylvania

Update on the Use of Viral Specific T-Cells
Michael Keller, MD
Children's National Medical Center

Adoptive T-Cell Therapy for Cancer: Does Raw Material Matter?
Daniel  J. Powell, Jr., PhD
University of Pennsylvania

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