Non-IgE Adverse Reactions to Foods: Improving Diagnosis and Treatment

This interactive course aims to improve the diagnosis and treatment of patients suffering from non-IgE mediated food allergy. It provides information about the presentation, triggers, and diagnostic tools to help allergy professionals more accurately differentiate between non-IgE mediated food allergy and food intolerance. The course also gives a lengthy discussion about management strategies and answers to common patient questions.

Target Audience

  • Allergist/immunologists
  • Fellows-in-Training
  • Allied Health Professionals

Learning Objectives

Upon completion of this activity, participants should be able to:

  1. Identify non-IgE mediated food allergies
  2. Differentiate between food intolerances and non-IgE mediated food allergies
  3. Select appropriate diagnostic tools for non-IgE mediated food allergies
  4. Answer common practical questions that arise with non-IgE mediated food allergies
Available credit: 
  • 0.50 Attendance
    Attendance credit.
  • 0.50 CE
    CE credit.
  • 0.50 CME
    CME credit.
Course opens: 
Course expires: 

Faculty are listed in alphabetical order.

Course Authors
Theresa Bingemann, MD
Rochester General Hospital, Rochester, NY
Relevant relationships: None

Jean-Christoph Caubet, MD
University Hospital of Geneva, Geneva, Switzerland
Relevant relationships: None

Stephanie Leonard, MD 
University of California, San Diego, San Diego, CA
Relevant relationships: None

Adverse Reactions to Foods Committee Course Reviewers
David M. Fleischer, MD FAAAAI
Children's Hospital Colorado, Aurora, CO 
Relevant relationships: Intrommune Therapeutics, INSYS Therapeutics, Inc, Aimmune Therapeutics, DBV Technologies, Kaleo Pharma, BEFORE Brands: consultant; Nestle Nutrition Institute: speaker; Aimmune Therapeutics and DBV Technologies: Grant support to institution

Anna Nowak-Wegrzyn MD FAAAAI
Icahn School of Medicine at Mount Sinai​​​​​​, New York, NY
Relevant relationships: ​Merck: advisory board; Nestle, Thermofischer, and Mead Johnson: speaker, and the International Association of FPIES: chair

CME Committee Reviewers
Sara A. Lowe, NP
Medical College of Wisconsin, Milwaukee, WI
Relevant relationships: Fight Asthma Milwaukee: Clinical Quality Improvement Committee

Johns Hopkins University, Baltimore, MD
Relevant relationships: None

Kristin C. Sokol, MD
National Institutes of Health, Bethesda, MD
Relevant relationships: Medical expert review

AAAAI Disclosure Policy
Pursuant to the Code of Ethics for the American Academy of Allergy, Asthma & Immunology (AAAAI) and the Standards for Commercial Support of Continuing Medical Education of the Accreditation Council for Continuing Medical Education, the AAAAI requires disclosure of certain information from faculty members of educational activities designated for CME credit by the AAAAI. Prior to the activity, authors and reviewers are required to disclose all relationships that meet the following parameters:

  • Employment. Name of employer and job title.
  • Financial interests. All organizations, other than the employer, from which the faculty member or a member of his/her immediate family or household receives annual remuneration in any amount (including grants, honoraria and consulting fees).
  • Research interests. All organizations which support research projects for which the faculty member or member of his/her immediate family or household serves as an investigator.
  • Legal Consultation Services/Expert Witness Testimony: All topics on which the faculty member provided legal consultation and/or expert witness testimony during the previous calendar year.
  • Organizational interests: All organizations, other than the AAAAI, for which the faculty member holds volunteer positions.
  • Gifts. All organizations from which the faculty member or a member of his/her immediate family or household have received a gift of any amount in the last year.
  • Other interests. All interests of the faculty member or a member of his/her immediate family or household that would be judged by a majority of his/her peers to be more than casual and/or likely to impact his/her ability to exercise independent judgment. This includes any financial interest in or relationship with any manufacturer of a commercial product, and any financial interest or relationship with any organization that provides commercial support to AAAAI-sponsored educational activities.

The information disclosed by the speakers and planning committee was reviewed in accordance with the AAAAI Disclosure Policy. All potential conflicts of interest were resolved by the planners, faculty, and reviewers prior to their participation in the development of this activity.

Accreditation Statement
The American Academy of Allergy, Asthma and Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation Statement
The American Academy of Allergy, Asthma & Immunology designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CE Designation Statement
The American Academy of Allergy, Asthma, & Immunology (AAAAI) is a Provider, approved by the California Board of Registered Nursing, Provider #10704, for up to 0.50 Contact Hours.

Medium and Method of Physician Participation
Follow these steps to complete the activity:

  1. Register for the activity.
  2. Review the CME and Disclosure information.
  3. Complete all required components.
  4. Complete the post-test. You must achieve a score of 70% or higher on post-tests to claim credit.
  5. Complete the activity evaluation.
  6. Claim your credits. Enter only the number of credits earned based on your participation in the activity.
  7. Print or save your certificate.

AAAAI Privacy Policy
To verify your participation in educational activities, you may be asked to provide your name, contact information, and/or other descriptors. The AAAAI will not release this information to outside entities. It may be used internally to inform you of other AAAAI educational activities. If you wish to have your information excluded from this process, please contact us at

Release date
Original release date: 2/21/2018. Valid for credit through 2/20/2021.

Available Credit

  • 0.50 Attendance
    Attendance credit.
  • 0.50 CE
    CE credit.
  • 0.50 CME
    CME credit.


Please login or register to take this course.

Required Hardware/software

One of the two latest versions of Google Chrome, Mozilla Firefox, or Safari. Internet Explorer is no longer supported.

Note: Links within the course will open according to your internet brower settings, either in a new tab or new window.