Demystifying IgE-Mediated Cow’s Milk Allergy: Diagnosis and Management: Revised 2021 Update

Cow's milk allergy is a common allergic problem for infants and young children. The clinical presentation is not always straightforward; diagnosis and management of complex cases can be challenging and impact quality of life. This online module is designed to help physicians and other healthcare professionals diagnose and manage cow's milk allergy in their practices.

This is the revised 2021 update to the course originally published in 2018.


Click the link to open a PDF of the references from this course.
PDF icon Demystifying Cow's Milk Allergy References.pdf

Target Audience

  • Allergist/immunologists
  • Fellows-in-Training
  • Allied Health Professionals

Learning Objectives

Upon completion of this activity, participants should be able to:

  1. Describe the prevalence and natural history of cow’s milk allergy
  2. Identify the symptoms seen with IgE-mediated cow’s milk allergy
  3. Select appropriate diagnostic tools and interpret test results to make an accurate diagnosis of cow’s milk allergy
  4. Outline effective strategies for practical management of cow’s milk avoidance
  5. Explain the nutritional risks of cow’s milk allergy
  6. Demonstrate how to replace the nutrients lost on the milk elimination diet through appropriate substitution
Available credit: 
  • 0.50 Attendance
    Attendance credit.
  • 0.50 CE
    CE credit.
  • 0.50 CME
    CME credit.
Course opens: 
Course expires: 

Content Authors
Aikaterini Anagnostou, MD PhD
Texas Children's Hospital, Houston, TX
Relevant relationships: None

Raquel Durban, MS RD CSP LDN
Asthma & Allergy Specialists, PA, Charlotte, NC
Relevant relationships: None

Marion Groetch, MS RDN
Mount Sinai School of Medicine, New York, NY
Relevant relationships: Speaker: Nutricia North America, Mead Johnson 

Irene Mikhail, MD
Nationwide Children's Hospital, Columbus, OH
Relevant relationships: None

Content Reviewers
Thomas Miller, MD FAAAAI
Allergy Associates of Western Michigan, Grandville, MI
Relevant relationships: AstraZeneca: asthma

AAAAI Disclosure Policy
Pursuant to the Code of Ethics for the American Academy of Allergy, Asthma & Immunology (AAAAI) and the Standards for Commercial Support of Continuing Medical Education of the Accreditation Council for Continuing Medical Education, the AAAAI requires disclosure of certain information from faculty members of educational activities designated for CME credit by the AAAAI. Prior to the activity, authors and reviewers are required to disclose all relationships that meet the following parameters:

  • Employment: Name of employer and job title.
  • Financial interests: All organizations, other than the employer, from which the faculty member or a member of his/her immediate family or household receives annual remuneration in any amount (including grants, honoraria and consulting fees).
  • Research interests: All organizations which support research projects for which the faculty member or member of his/her immediate family or household serves as an investigator.
  • Legal Consultation Services/Expert Witness Testimony: All topics on which the faculty member provided legal consultation and/or expert witness testimony during the previous calendar year.
  • Organizational interests: All organizations, other than the AAAAI, for which the faculty member holds volunteer positions.
  • Gifts: All organizations from which the faculty member or a member of his/her immediate family or household have received a gift of any amount in the last year.
  • Other interests: All interests of the faculty member or a member of his/her immediate family or household that would be judged by a majority of his/her peers to be more than casual and/or likely to impact his/her ability to exercise independent judgment. This includes any financial interest in or relationship with any manufacturer of a commercial product, and any financial interest or relationship with any organization that provides commercial support to AAAAI-sponsored educational activities.

The information disclosed by the speakers and planning committee was reviewed in accordance with the AAAAI Disclosure Policy. All potential conflicts of interest were mitigated by the planners, faculty, and reviewers prior to their participation in the development of this activity.

Accreditation Statement
The American Academy of Allergy, Asthma and Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation Statement
The American Academy of Allergy, Asthma & Immunology designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CE Designation Statement
The American Academy of Allergy, Asthma, & Immunology (AAAAI) is a Provider, approved by the California Board of Registered Nursing, Provider #10704, for up to 0.50 Contact Hours.

Credit Claiming Period
Credit claiming for this activity will expire at 11:59 pm on April 1, 2023. Requests to claim credit on or after April 1, 2023 will be subject to an administrative fee.

Medium and Method of Participation
Follow these steps to complete the activity:

  1. Register for the activity.
  2. Review the CME and Disclosure information.
  3. Complete all required components.
  4. Complete the post-test. You must achieve a score of 70% or higher on post-tests to claim credit.
  5. Complete the activity evaluation.
  6. Claim your credits. Enter only the number of credits earned based on your participation in the activity.
  7. Print or save your certificate.

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Credit claiming questions should be directed to

Available Credit

  • 0.50 Attendance
    Attendance credit.
  • 0.50 CE
    CE credit.
  • 0.50 CME
    CME credit.


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